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2020;10(12):e040647
The SURPASS-2 trial (N=1,879), published in the New England Journal of Medicine in 2021, used exactly this 4-week step schedule and still reported GI adverse events as the most common reason for discontinuation [3]
You may also experience fatigue and headaches due to reduced calorie intake or dehydration
These findings suggest a potential mechanism through which GLP-1 signaling may reduce glycation-related cellular stress
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