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Older adults (60+) May benefit from extended escalation intervals (6 weeks per step instead of 4) due to: Slower metabolic adaptation Increased medication sensitivity Higher likelihood of comorbid conditions Potential polypharmacy interactions Body Weight and Composition Factors Unlike some medications dosed per kilogram of body weight, cagrilintide uses fixed dosing regardless of baseline weight

a 2025 IV pilot in two adults used 10 mg and 20 mg single infusions and reported no adverse effects (Lee et al., Alternative Therapies in Health and Medicine)

Receptor desensitization: Continuous use beyond 68 weeks may lead to diminished response