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One participant stated: "While on Mounjaro, I couldn't smoke, but after stopping it for about a month, I went back to smoking." (Male, 8 months on GLP-1 therapy) "During the period of use, the need for nicotine noticeably decreased, but after the treatment period ended, the desire to smoke gradually increased." (Male, 6 months on GLP-1 therapy) In contrast, a subset of participants reported no observable perceived impact of GLP-1 on their smoking behavior

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It is also contraindicated to use semaglutide with other GLP-1 receptor agonist like tirzepetide or liraglutide