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(2017) Cardiovascular safety and benefits of GLP-1 receptor agonists
2024;121(19):e2315348121
The body tissue distribution studies show a very high concentration of LC in mature spermatozoa and luminal fluid of cauda epididymis [26]
Upon ligand binding, GLP-1R activation enhances glucose-dependent insulin secretion, suppresses glucagon release, delays gastric emptying, and reduces appetite, collectively improving glycemic control and promoting clinically meaningful weight reduction [19]
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