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Similar to myocardial ischemia, which often precedes the development of HF, it is characterised by low-flow state promoting blood stasis, due to impaired contractility and ventricular dilatation, a prothrombotic condition driven by low-grade inflammation, and endothelial dysfunction (248, 255)
The convenience is obvious, but absorption rates can vary more than with injections, and some patients report that the oral formulation produces different side effect profiles compared to injectables
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Yes, side effects can frequently be addressed by titrating the dose
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