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How to safely switch from semaglutide to tirzepatide The first step to switching from semaglutide to tirzepatide is to schedule an appointment with a healthcare provider

Patients should disclose a history of pancreatitis, gallbladder disease, severe gastrointestinal disease, kidney disease or dehydration risk, use of diabetes medications such as insulin or sulfonylureas, pregnancy or plans for pregnancy, any personal or family history of medullary thyroid carcinoma or MEN2, and a history of diabetic retinopathy

Current recommendations from anesthesiology, gastroenterology, bariatric surgery, obesity medicine, and endocrine organizations are examined to provide a comprehensive overview of contemporary perioperative practice

A separate retrospective study published in 2025 in JAMA Ophthalmology compared patients who took either oral or subcutaneous semaglutide for type 2 diabetes and matched them to control based on race, sex, A1c and comorbid conditions such as DR, sleep apnea, hypertension and hyperlipidemia