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Fe Porphyrin-based SOD Mimic and redox-active compound, (OH)FeTnHex-2-PyP 4+ , in a Rodent Ischemic Stroke (MCAO) model: efficacy and pharmacokinetics as compared to its Mn Analogue, (H 2 O)MnTnHex-2-PyP 5+
demonstrated that the liberation of heme from Hb is a necessary step towards vaso-occlusion (Belcher et al., 2014)
The tradeoff you get in exchange comes down to absorption kinetics
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