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NK Cell Cytotoxicity Impairment Natural Killer cells provide first-line immune surveillance without prior antigen sensitisation, making their function critical in immune defence against diabetes

Genetic variations: Certain glutathione S-transferase (GST) gene polymorphisms (e.g., GSTM1, GSTP1) increase autism risk and severity, especially when combined with prenatal exposures

Mitochondrial dysfunction in the striatum is a primary feature of Huntingtons disease (Oliveira, 2010)

The structural modifications that extend its half-life also mean it accumulates in the body over time, which is why dose escalation protocols start low and increase gradually