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Despite this rapid clearance, SFN and its conjugates effectively distribute to various tissues, including the prostate, lung, and bladder, where they can accumulate at concentrations sufficient to exert biological effects, as demonstrated in both rodent models and human tissue biopsies (47, 48)

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Neuroimaging and post-mortem studies reported excessively elevated glutamate levels in the plasma, cerebrospinal fluid, and brains of patients with depression (Zarate et al., 2008)

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