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The C20 fatty di-acid moiety, attached at Lys-20 via a Glu2AEEA linker, enables reversible albumin binding and is structurally analogous to, but longer than, the C18 chain used in semaglutide
The authors never discussed the possibility that PGN complexed with the added proteins to effectively reduce the active concentration of the PGN, or the fact that PGN and CGN are two different molecules, by molecular weight and physiochemical properties, and that those properties could have played a role in the differences observed
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