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Our study is first to demonstrate novel molecular mechanisms involved in the sensitization of PTC cells to ferroptosis inducer- we show that RSL3, a potent direct GPX4 inhibitor, effectively reduces the viability of thyroid cancer lines with various mutational backgrounds compared to HThF control cell line in a dose-dependent manner

Bikle DD, Vitamin D (2014) metabolism, mechanism of action, and clinical applications

Tumor-derived DAMP proteins are overexpressed in various tumor types and are strongly correlated with disease severity and poor prognosis [257]

Their conclusion: the FDA considers a products classification based on its intended use , not its disclaimers