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Acetaldehyde crosses the blood-brain barrier and binds to brain proteins, impairing synaptic transmission and producing the characteristic "cotton wool" cognitive dulling patients describe as brain fog
Without sufficient B12, this sheath can weaken, which may explain symptoms such as tingling, numbness, memory issues, or brain fog. From an energy standpoint, B12 supports the methylation cycle , a chemical pathway involved in energy metabolism and detoxification
PMID 8075776
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