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In a recent randomized, double-blind, placebo-controlled trial, obese adults without diabetes were assigned to the exercise group, the GLP-1RA (Lira) group, and the exercise+Lira group
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Should retatrutide receive a positive regulatory decision, it would then be subject to a health technology appraisal (HTA) by NICE (National Institute for Health and Care Excellence) to determine its clinical and cost-effectiveness relative to existing treatments
10.1016/j.jchromb.2008.01.016 61 RomanoM.CianciE.SimieleF.RecchiutiA
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