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4-HNE is involved in PD pathology by covalently modifying -syn to promote its aggregation, disrupting the ubiquitin-proteasome system, and interfering with dopamine receptor function, and has been found to alter dopamine transport, contributing to dopamine loss (82, 86, 88)

Inadequate protein, B vitamins, and methylation can inhibit its production

15 Additionally, aspirin-loaded nanoparticles combined with other bioactive molecules, such as curcumin 20 or resveratrol, 21 have demonstrated enhanced anticancer effects in preclinical models