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GLP-1 medications substantially decrease appetite, and many patients inadvertently consume far fewer calories than their body requires for optimal energy levels
This suggests that substantial unintentional weight loss in placebo patients likely reflected underlying health problemssuch as cancer, heart failure, or other serious conditionsrather than therapeutic benefit
However, accumulating ChIP-seq data indicates that NRF2 predominantly binds intronic or distal intergenic regions (Malhotra et al, 2010
They can determine the best course of action
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