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Murine experiments with Sm-TSP-2/Sm29 vaccination resulted in higher reductions of worm burden and granulomata, with elicitation of total IgG, IgG1 and IgG2a antibodies with IFN- and TNF cytokine production across groups, and a Th1 response with increasing antibody titers following additional booster immunizations (63)
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Oral KPV survives digestion and acts on gut-associated lymphoid tissue, which modulates systemic inflammation
GLP-1 receptor agonist medications like semaglutide (Ozempic and Wegovy) and tirzepatide (Mounjaro) work by mimicking this natural hormone, though at higher and more sustained levels than the body would produce on its own
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