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The questions a serious diligence pass has to answer are whether the estate covers the formulation you intend to commercialize, whether it blocks the most likely generic design-arounds, whether freedom-to-operate is clear against Sanofi's method-of-use filings and against Indiana University's foundational scaffold estate, and whether the estate is structured to support the pediatric and geographic expansion strategies that drive the back half of the asset's lifecycle value
2,6 Although the majority of patients experience mild adverse reactions, such as hepatitis, cholestasis or asymptomatic liver enzyme elevation, APAP hepatotoxicity is generally estimated to account for approximately 48% of acute liver failure diagnoses
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