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Yes, certain medications including corticosteroids, atypical antipsychotics, and some hormonal therapies can promote weight gain or worsen insulin resistance, potentially counteracting tirzepatide's benefits
The results of the meta-analysis indicated that GLP-1 receptor agonists reduced the risk of fatal or non-fatal stroke compared with the placebo (RR: 0.85
However, some comparative studies in animals suggest that oral ingestion of the peptide can also have systemic effects
Regarding the inclusion criteria of only including RCTs and the high heterogeneity shown in the analysis, we believe the limited number of participants may have caused bias in the results of our non-significant analysis
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