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Selectively targeting glutamine uptake by L--Glutamyl-p-nitroanilide (GPNA), an inhibitor of glutamine transporter SLC1A5, showed a reduction of tumor proliferation in a preclinical 3D model and tumor growth suppression in a xenograft when combined with castration of mice [152]
Moreover, the metabolic pathways associated with the nutritional regulation by dietary L-carnitine supplementation in zebrafish were determined
Summary: Joint pain is not established as a direct side effect of Mounjaro (tirzepatide), though musculoskeletal symptoms occur in 3-7% of patients at rates similar to placebo
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