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An NNMT inhibitor like 5-amino-1MQ could help by stimulating the synthesis of NAD+, a vital cofactor in the electron transport chain
Additionally, Methionine may increase stimulation of the mammalian target of Rapamycin (mTOR)
Both are copper-binding tripeptides, but they have different amino-acid sequences
A 2021 review in Nature Reviews Molecular Cell Biology describes a gradual drop in tissue and cellular NAD+ across aging in rodents and humans, and links that fall to metabolic disease, cognitive decline, and sarcopenia [1]
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