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Pre-existing b12 deficiency or low-normal levels Anyone starting semaglutide with documented b12 deficiency or levels in the low-normal range (200 to 400 pg per milliliter) should receive supplementation
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Some people also notice an improvement in their overall sense of well-being and a reduction in symptoms associated with deficiency, such as tingling or numbness in the extremities
The starting dose is typically 25 units (0.15mg) twice weekly
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