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These medications work by targeting hormones that regulate appetite and metabolism, helping patients achieve significant weight loss and improve overall health
However, unlike thiazide and loop diuretics, SGLT2-i are not associated to systemic sympathetic hyperactivity, typically found in diabetes
Clinical trials have demonstrated weight loss ranging from approximately 10% with GLP-1 agents at weight management doses (e.g., semaglutide 2.4 mg in the STEP trials) to over 20% with tirzepatide at higher doses (SURMOUNT trials)
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