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In this line, the authors of one of the first studies on programmed erythrocyte death demonstrated that erythrocytes from patients with different forms of anemia (sickle cell anemia, thalassemia, and G6PDdeficiency) are more susceptible toward oxidative stress as compared with erythrocytes from healthy volunteers
However, expression of the gene encoding LCAD (ACADL) is very low and restricted in humans and, therefore, LCAD does not contribute, to any significant extent, to long-chain fatty acid oxidation
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