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The LDL receptor spans the plasma membrane and it is the extracellular domain that is responsible for apoB-100/apoE binding
There was no strong reason to take such supplements before the study, and now this well-done study suggests there may be harm
If solution storage is necessary, researchers commonly use sterile buffers around pH 56, aliquot to reduce freezethaw exposure, and store refrigerated shortterm (often referenced as up to ~30 days at ~4C (39F) as general guidance), freezing when not in use depending on the protocol
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