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Cell Immunol (2017) 322:1525
They are produced through a non-enzymatic glycation process called the Maillard reaction, which uses the carbonyl groups of reducing sugars and the free amino groups of proteins as substrates (Figure 2) (81)
To assess pharmacodynamics, we used an MV4;11 orthotopic xenotransplantation model of AML and observed stereoselective ENL degradation after three administrations of ( R )-dHTC1 or ( S )-dHTC1 (50 mg kg 1 ) (Fig
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