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3.2 Other Bacterial Mechanisms Influencing Levodopa Bioavailability Small intestinal bacterial overgrowth (SIBO), a condition characterised by an increased concentration of bacteria above 10 5 colony-forming units/ml and/or presence of colonic-type bacteria in the small intestine [41, 42], is reported in up to 54% of PD patients, and associates with development of motor complications and variability in motor response [43,44,45]

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Online sources sometimes group this treatment with skin lightening injections, however that description oversimplifies its biological role

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