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L-carnitine supplementation reduces hypertension, hyperlipidemia, hyperglycemia, insulin-dependent diabetes mellitus, insulin resistance, obesity, inflammation and oxidative stress

Research has shown that collagen synthesis is specifically reduced in hypothyroidism, which means many classic hypo symptoms like dry skin, joint pain, and brittle hair may be partly a collagen problem, not just a thyroid hormone problem

However, its levels naturally decline with age, and obtaining sufficient amounts through diet alone can be challenging

Nearly half of the research studies included in this review performed LCMS based metabolomics on plasma samples (Kupfer and Regier 2011