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However, once a multi-dose pen is first used, the in-use period (discussed in the next section) takes precedence over the printed expiration date

But the medications which include those sold under brand names Ozempic, Wegovy, Mounjaro and Zepbound can come with some uncomfortable and potentially risky side effects, including nausea, diarrhea, vomiting, constipation and dehydration, as well as bone and muscle loss

In TRIUMPH-4, nausea reached up to 43% at the 12mg dose, and retatrutide introduced a dysesthesia (altered skin sensation) signal not seen with semaglutide or tirzepatide

Anti-icodec antibodies were assessed following IcoSema and icodec administration