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Recent research shows that bitter substances that activate TAS2R38 can also increase glucagon-like peptide 1 release.[ref] Related article : Bitter Taste Receptors Berberine: One bitter substance that activates TAS2R38 is berberine .[ref] Berberine is readily available as a supplement and also impacts blood glucose levels

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Clinical RCT 2014 Phase 2b RCT in postoperative ileus (bowel resection inpatients) Beck, Sweeney, and McCarter (Ipamorelin 201 Study Group) reported a multicenter, double-blind, placebo-controlled proof-of-concept study in bowel-resection inpatients