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The most common adverse effect involves scalp irritation, occurring in 5-10% of users and typically presenting as itching, dryness, flaking, or dermatitis
It is studied for its selective action on lipolytic pathways without activating the IGF-1 receptor
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The stratum corneum , the outermost 1020 microns of dead corneocytes embedded in lipids, is the principal barrier, and it strongly favors small, lipophilic molecules
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