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Repeatedly injecting into the same spot can cause local tissue changes, such as injection-site nodules or reactions, and less commonly lipohypertrophy (a localised thickening or hardening of fatty tissue), all of which can impair drug absorption and affect treatment outcomes

Cagrilintide is an amylin receptor agonist, which operates through a different pathway than any of the three receptors retatrutide targets

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The study design was approved by the Ethics Committee of the first Affiliated Hospital of Sun Yat-Sen University ([2012]248)