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Under the MHRA's 'borderline products' guidance, transdermal patches designed to deliver active substances systemically would typically be classified as medicines requiring marketing authorisation
149 Moreover, Baggio et al 150 established cardiomyocyte conditional GLP-1R (Glp1r CM-/- ) and HCN4 knockout mice models, and found that treatment with both Liraglutide and lixisenatide elevated HR in vivo in the wild types, and attenuated in Glp1r CM-/- mice, which could be blocked by a -adrenoceptor antagonist
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Lee M, Saver JL, Hong KS, et al
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