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Data analysed by one-way ANOVA, multiple comparison, Bonferroni post hoc test ( f , g , j , l - n , r and s ), two-way repeated measures ANOVA to assess main effects of treatment ( b , c , e and k ), and ANCOVA computed with calR using body weight as a covariate ( p )

In contrast, GLP-1/glucagon co-agonists, such as cotadutide and survodutide, preferentially enhance lipid oxidation, energy expenditure, and hepatic fat clearance, conferring stronger effects on steatosis resolution relative to GIP-based combinations

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That magnitude is exactly why the muscle question matters: the more total weight you lose, the more total lean mass rides along with it