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In a Phase IIb trial involving 128 adults with obesity and biopsy-confirmed MASH and stage F2 or F3 fibrosis, subcutaneous efruxifermin at 28 mg or 50 mg weekly for 96 weeks resulted in higher rates of improvement in fibrosis of one or more stage without worsening of MASH (46% and 75%, respectively) than placebo (24%) [49]

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