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Semin Cancer Biol 66:89100
PGC-1alpha stimulates mitochondrial biogenesis and participates in the regulation of both carbohydrate and lipid metabolism while PPGC-1alpha is the active form of PGC-1alpha
All cited studies are conducted in cellular or rodent systems consistent with the molecule's RUO classification
Given the complexity of the disease, it is therefore not surprising that dissecting cause and effect is not a simple matter
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