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In this review we will focus on the effects of metformin on the gut and how its action within the intestine and on the intestinal enterocytes can explain at least some of the glucose-lowering effects of metformin, the increase in lactate concentrations and GI side-effects of this commonly used drug

This is another reason why higher concentrations (10-20mg/mL) are preferred for higher doses, and why the reconstitution charts emphasize these concentrations for the escalation and maintenance phases

Specifically, analyzed were the affected brain areas (04), cerebral (NTP-7, Level 3), cerebellar cortex (NTP-7, Level 6), and hippocampus, thalamus, and hypothalamus (NTP-7, Level 3) as follows (score 0 indicates no histopathologic change): score 1: small, patchy, complete, or incomplete infarcts (10% of the area affected)

while toxic, in small enough doses, it shouldnt be too harmful