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These studies indicate that overproduction of glutathione drives the survival and growth of a small subset of lymphoid tumor cells in 3D gels and xenografts, likely TIC or TIC-like cells, and that glutathione is selectively required for tumor growth in females of a mouse model of lymphoma

Frisvad JC, Hubka V, Ezekiel CN, Hong SB, Novkov A, Chen AJ, et al

In GCLM KO mouse liver, constitutive activation of AMPK was observed as measured by levels of phosphorylated AMPK and phosphorylated ACC

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