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The peptide functions as a precision senolytic agent by competing with endogenous FOXO4 for p53 binding, releasing the tumor suppressor protein to trigger apoptosis specifically in cells that have accumulated the senescence-associated secretory phenotype (SASP) markers
The fibroblast populations that maintain mucosal connective tissue express the same collagen synthesis pathways, and SPARC and decorin upregulation data from Pickarts transcriptomic analyses covers targets common to fibroblast populations across tissue types (PMID: 25904764)
Applying peptide protocols to children with eczema would be off-label to an extreme degree, and the developing immune system and skin barrier present additional unknowns
and C.W., 82203156 to S.Z., 824B2085 to Liang Zhu), the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (2025-I2M-KJ-003, 2025-I2M-XHZY-016, 2025-I2M-GCC-002 and 2023-I2M-2-004 to C.W.), the National Key Research and Development Program of China (2023YFC3503200 to S.Z), the National High Level Hospital Clinical Research Funding (2025-LYZX-D-B04 to D.L., 2025-LYZX-C-B01 to C.W)
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