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Under control conditions, the OTA-associated blue auto-fluorescence showed a sharp increase in the sinusoidal blood within seconds after intravenous injection, followed by a slow decrease (Supplement Video 1A

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A significant change in pH affects the structure of all macromolecules, for instance, presence of a higher proportion of H + or low pH solution cleaves DNA double helix strands by protonating the DNA phosphodiester groups and consequently destabilizing the hydrogen bonds linking DNA nitrogenous bases guanine and cytosine (G-C) ( E