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Despite the substantial conformational dynamics when bound to AMY 3 R, Cagri maintains the bypass conformation across the motions, likely arising from the consistent TMD and linker interactions between RAMP3 and CTR that enable robust engagement of residues within the Cagri bypass motif
It can serve not only as a core tool for metabolic research, but also play a role in the study of more metabolismrelated diseases including polycystic ovary syndrome and metabolic syndrome, while helping to further elucidate NNMTrelated energy metabolism mechanisms
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