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[17] In contrast, supplementation with glutathione is incapable of increasing cellular glutathione since the GSH concentration found in the extracellular environment is much lower than that found intracellularly by about a thousand-fold
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As MOTS-c activates AMPK and NRF2, it also indirectly suppresses the mTOR (mechanistic target of rapamycin) pathway, the master growth and anabolism regulator that, when chronically overactivated, accelerates the accumulation of senescent cells
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