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In the PIONEER clinical trials, once-daily oral semaglutide demonstrated better efficacy compared to placebo, sitagliptin, empagliflozin, liraglutide, and dulaglutide in reducing cardiovascular risk [12]
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If B12 deficiency is caused by a lack of B12 in the diet a change in diet is requested, or alternatively, a daily vitamin pill should be administered together with a meal
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