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J., & Yim, S
Hayes JD, Pulford DJ
2.4 Glutaminolysis Glutaminolysis plays a pivotal role in GBM metabolism by supporting fatty acid synthesis by producing a flux of NADPH (a reduced cofactor) via malic enzyme activity, so much so that it appears to provide an abundance of NADPH for other anabolic processes such as nucleotide production on top of primarily lipid synthesis (68)
In humans, passive transport of GSH from the plasma into the cell is not thermodynamically favorable, because intracellular GSH levels are much higher than the plasma [6]
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