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Based on UK guidelines and common practice, a GP surgery may refuse to give a B12 injection a day earlier than scheduled for a patient with Pernicious Anemia for a few key reasons: Clinical Guidelines and Protocols Standard Treatment Schedules: The NHS and professional bodies like the British Society of Haematology have established guidelines for B12 injections for Pernicious Anemia

In its absence, peripheral neuropathy can occur, leading to numbness in your extremities

Due to change in size and shape, the movement of red blood cells from bone marrow to the bloodstream become ineffective, often leading to megaloblastic anemia

He started with three 1000mcg over the course of a week, but then only one a week, then one every two weeks