Kulak MV, Cyr AR, Woodfield GW, Bogachek M, Spanheimer PM, Li T, Price DH, Domann FE, Weigel RJ
In published preclinical work, inhibiting NNMT is associated with elevated intracellular NAD and SAM, reduced lipogenesis and smaller adipocytes in cell and diet-induced-obese rodent models, and is studied in the context of insulin sensitivity and muscle function
Therefore, we conducted a systematic review to examine whether OA progression in patients with type 2 diabetes was affected by metformin treatment The systematic review revealed that type 2 diabetes patients treated with metformin showed a lower incidence of knee arthroplasty (Fig
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