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Autoimmune Diseases Autoimmune Diseases Lupus (SLE) Scleroderma (systemic sclerosis) Inflammatory myositis (polymyositis, dermatomyositis) Mixed connective tissue disease Autoimmune thyroid diseases (Hashimotos thyroiditis, Graves disease) Autoimmune hepatitis Primary biliary cirrhosis In-depth: Lupus and ANA Systemic Lupus Erythematosus (SLE) is the autoimmune disease most closely associated with positive ANA tests