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The nine tissue systems now documented in the preclinical literature were not predicted by computational models or receptor-binding assays at the outset they were identified sequentially as researchers in different laboratories independently tested the compound against different experimental injury models and consistently found meaningful effects

Carvajal-Z O, Barradas-D DM, Hayward-Jo PM, Aguilar-Us MG, Nolasco-Hi C, Quero-Herr S, et al

doi:10.1038/s44321-024-00061-x 86