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Phase 2 monotherapy (Lau et al., 2021): 706 adults with overweight/obesity across 57 sites
When the amount of tyrosinase is reduced, the melanin formation process is also prevented, leading to brighter skin and less darkening
Women typically carry a higher percentage of body fat with preferential storage in gluteofemoral regions (hips, thighs, buttocks), while men tend to accumulate visceral and abdominal subcutaneous fat
The concentration of MSU crystals we used (1 mg/mL) had been found to be optimal beforehand on a limited dose-response curve (0.1, 1.0, and 10.0 mg/mL
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