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The role of autophagy adaptor proteins is to recognize ubiquitin-labeled mitochondria and also recognize microtubule-associated protein 1 light chain 3 (LC3) that interacts with ATG8 family proteins
doi: 10.1053/j.gastro.2016.12.050 106 BerthoudHRNeuhuberWL
Aged mice (22 months, equivalent to roughly 65 to 70 human years) treated with MOTS-c three times per week doubled their running capacity on treadmill tests
The cost of these medications can increase with higher dosages, combination therapy with other diabetes medications, and long-acting formulations that are administered less frequently
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