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Topical application studies report minimal adverse effects

In male mice subjected to unpredictable chronic mild stress, peripheral TRP degradation was enhanced, and KYN was preferentially metabolized toward the QA branch of the KP within the amygdala and striatum, whereas the opposite was observed in the cingulate cortex [67]

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This may give some readers pause if theyre familiar with lithium as used for psychiatric disorders, namely major depression and bipolar disorder